Did YOU know?

Important facts about BOTOX® Cosmetic:

  • 1st FDA-approved botulinum toxin to temporarily improve moderate to severe frown lines between the brows in people aged 18 to 65
  • Our 10th year of real, noticeable results that are proven to last up to 4 months
  • #1 prescribed product of its kind in the US
  • ~11 million procedures have been performed since 2002
  • Approved in ~72 countries for aesthetic use (called VISTABEL outside the US)
  • BOTOX® Cosmetic has a record of experience that your healthcare professional knows and trusts
  • High satisfaction rate (over 95% since May 2011) among people surveyed who were treated with BOTOX® Cosmetic.

What is BOTOX® Cosmetic?
Millions of women already know BOTOX® Cosmetic - a nonsurgical treatment that helps temporarily improve moderate to severe frown lines between the brows. Those moderate to severe vertical lines between the brows are sometimes referred to as 1's, 11's, or 111's.

Why do I get 1's?
Years of squinting, concentrating, or frowning can cause your skin to furrow and crease. As time passes, your skin becomes less elastic and those moderate to severe frown lines remain- even when your muscles aren't contracting.

With BOTOX® Cosmetic, you can get real, noticeable results and still look like yourself. So, you can still frown or look surprised, but  without the wrinkles and creases between your brows.

Why consider BOTOX® Cosmetic?
Botulinum toxins are biologics, a type of purified protein. Since biologics are made from living things, they are unique. So, even if a  botulinum toxin product has the same ingredients as another, they may not have the same effect.

Because biologics have a complex structure, it is difficult to recreate a product without knowing exactly how it's made (which is specific to each manufacturer). That's why the amount of the dose (Unit dosing) and formulations are different between products. Be sure to ask your healthcare professional if BOTOX® Cosmetic is right for you.

No surgery. No recovery time.
BOTOX® Cosmetic treatment is a quick, 10-minute procedure that requires no downtime or recovery - it's often called a lunchtime procedure.

With a few tiny injections, BOTOX® Cosmetic blocks nerve impulses to the muscles in your forehead called the "corrugator" and "procerus" muscles reducing their movement. This decreased muscle activity helps lessen the appearance of moderate to severe frown lines between the brows for real, noticeable results.

A patient's perspective
Name: Tresha
Age: 35
Occupation: Senior financial analyst
Residence: California
Diagnosis: Severe underarm sweating

Prior to BOTOX® treatment:
"I didn't go out with my friends because I would have to try to hide my underarm sweating."

Hiding the problem:
Paper towels, shoulder pads, bra inserts
"I would have to continuously change paper towels and tissues beneath my arms because I'd sweat through them or they'd fall out."

Failed treatments:
Prescription antiperspirant, over-the-counter antiperspirants
"Drysol® didn't work for me very well, and Certain Dri® was even less effective."

After BOTOX® treatment:
"Sweating is not something that's controlling my daily routine anymore. Now I can do things like standing up in front of a group of people at work without having to look down to see if I'm sweating under my arms."

"Thankfully, BOTOX® treatments have helped me control my underarm sweating."

What do I need to know about BOTOX® Cosmetic?
BOTOX® Cosmetic may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have problems swallowing, speaking, or breathing, or if you notice spread of toxin effects any time (hours to weeks) after injection of BOTOX® Cosmetic. If this happens, do not drive a car, operate machinery, or do other dangerous activities.

How fast will I see results?
BOTOX® Cosmetic starts to work within 24 to 48 hours. In clinical trials, a majority of people saw significant improvement at 7 days, with results continuing to improve for up to a month.

How long will my results last?
Visible results have been proven to last up to 4 months. Your results may vary.

What does my healthcare professional need to know before my BOTOX® Cosmetic treatment?
Tell your healthcare professional about:

  • All your muscle or nerve conditions (eg, amyotrophic lateral sclerosis, myasthenia gravis, or Lambert-Eaton syndrome)
  • Any prescription or nonprescription medicines, vitamins, muscle relaxants, or herbal products you take, or if you have recently received an antibiotic by injection
  • All your medical conditions including previous or upcoming surgeries, weakness of forehead muscles, or any other facial abnormalities
  • If you are currently pregnant or plan on becoming pregnant
  • If you are currently breast-feeding or plan on breast-feeding
  • If you have received any other botulinum toxin product in the past, particularly in the last 4 months

What are the possible side effects with BOTOX® Cosmetic treatment?
Serious and/or immediate allergic reactions have been reported. Possible side effects include itching, rash, red itchy welts, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or get medical help right away if you are wheezing or have asthma symptoms, or if you become dizzy or faint. Other side effects of BOTOX® Cosmetic may occur, including dry mouth, discomfort or pain at  the injection site, tiredness, headache, neck pain, and eye problems, such as double vision, blurred vision, decreased eyesight, drooping eyelids, swelling of your eyelids, and dry eyes.

Can BOTOX® treatment help?
BOTOX® is FDA approved for severe underarm sweating when topical agents don't work. BOTOX® treatment helps control this condition by temporarily blocking the chemical signals from the nerves that stimulate the sweat glands. When the sweat glands don't receive chemical signals, the severe sweating stops.

What is treatment with BOTOX® like?
The procedure is relatively straightforward. A small volume of BOTOX® solution is injected into the affected underarm area through a very
fine needle. The needle is placed just under the skin, so you may experience some injectionrelated discomfort. You will receive multiple injections based on your doctor's assessment of the area that needs to be treated.

What should I expect after I have received BOTOX® treatment?
You should notice a significant reduction in underarm sweating within 4 weeks of your first treatment. There is a possibility that some sweat glands may be missed, and you may continue to experience some sweating from the untreated areas. If you do not see a significant reduction in sweating, you should contact your doctor and request a follow-up consultation.

How effective is BOTOX® treatment?
BOTOX® treatment is very effective. Clinical studies found the following ...

  • 57 out of 104 BOTOX® treated patients (55%) achieved an effective responsecompared to only 6 out of 108 treated without BOTOX® (6%)
  • 78 out of 104 BOTOX® treated patients (75%) achieved an effective response 4 weeks after treatment 1 compared to only 27 out of 1 08 treated without BOTOX® (25%)
  • 84 out of 104 BOTOX® treated patients (81 %) achieved a greater than 50% reduction in sweating -compared to only 44 out of 108
  • treated without BOTOX® (41 %)

How long does a BOTOX® treatment last?
In a clinical study, the median duration of response in BOTOX® patients was 201 days or 6. 7 months (i.e., half of the patients had a treatment duration of at least 201 days or 6. 7 months). It is not a cure; your symptoms will return gradually, and you will know when the time is right for another treatment. Your doctor will recommend a treatment strategy to ensure that you receive the best possible results with BOTOX® treatment.

Are there any safety concerns with BOTOX® treatment?
BOTOX® has been used therapeutically for over 16 years to treat a variety of medical conditions. It is approved in more than 75 countries. In fact, BOTOX® for therapeutic use remains one of the most widely researched medicines in the world.

Important Safety Information*
You should not be treated if you have an infection at the injection site or are hypersensitive to any of the ingredients. Serious allergic reactions and cardiac events have been rarely reported. If you think you're having an allergic reaction or other unusual symptoms, such as difficulty swallowing, speaking, or breathing, call you doctor immediately. Side effects include injection-site pain and bleeding, non-underarm sweating, infection, sore throat, flu, headache, fever, neck or back pain, itching and anxiety. Patients with certain neuromuscular disorders such as ALS, myasthenia gravis, or Lambert-Eaton syndrome may be at increased risk of serious side effects.

*Full prescribing information has been provided to your doctor.

Is BOTOX® treatment right for me?
Your doctor can help you decide if BOTOX® treatment is right for you. In order to make the right treatment decision, you should discuss
the following with your doctor before receiving BOTOX® injections:

  • Your doctor's experience with BOTOX® treatment
  • Effectiveness and important safety information about BOTOX®

You should tell your doctor if:

  • You are allergic to BOTOX® product or anything in the preparation
  • You have a neuromuscular disease such as amyotrophic lateral sclerosis, motor neuropathy, myasthenia gravis, or Lambert-Eaton syndrome
  • You have an infection at the intended site of injection
  • You are taking antibiotics or other prescription medications, such as curare, that may interfere with neuromuscular transmission
  • You are being treated with any medications

How can I find out if my insurance covers BOTOX® treatment?
In the US today, more than 85% of managed healthcare lives have coverage for hyperhidrosis. The BOTOX ADVANTAGE® Reimbursement Hotline can work with you and your physician to facilitate the reimbursement process.

To find out about what kind of coverage your plan offers for BOTOX®, talk to your doctor or call the BOTOX ADVANTAGE® Reimbursement Hotline at 1-800-530-6680, Monday through Friday, from 8 AM to 8 PM Eastern time.

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